H.Lee Moffitt Cancer Center & Research Institute
Alyson Fay
"DNA Damage Response in BC"

The main goal of this project is to determine the functional significance of the interaction between checkpoint kinase CHK2 and protein phosphatase PP2A.CHK2 plays an important role in the DNA damage response pathway, therefore we proposed to define this interation to further characterize the CHK2-mediated response. The CHK2-PP2A interaction was originally found in this lab by performing a yeast two-hybrid screen on human mammary gland cDNA using CHK2 as bait. A subunit of PP2A, namely B56alpha (also called B’alpha), was pulled out of this screen. The holoenzyme form of PP2A consists of an A structural subunit, a C catalytic subunit, and one of many B regulatory subunits. It is the B subunits that are thought to give PP2A its specificity. Since both CHK2 and subunits of PP2A have been found to be mutated in breast cancer tumors and cell lines, we hope that by defining this interaction we will be able to shed some light on its importance in breast cancer so that we may exploit it for therapeutic means.


H.Lee Moffitt Cancer Center & Research Institute
Ping Luo
"CAD Assisted Mammography"

The objective of the project is to identify the problem-solving model and cognitive components underlying non-cognitively-based and cognitively-based hypermedia learning. The other objective is to find out how the integration of cognition-based activities influences the performance of mammogram readers and if and how cognitively-based hypermedia training can help enhance retention, recognitions, and other performance in mammography interpretation education and decrease errors in detection and diagnosis. Another objective is to design a hypermedia prototype tutoring system on the basis of the identified cognitive model, factors, and empirical evidences. It will build up the residents’ confidence, skills, and experiences in extending their perception with computer-based interactions and knowledge construction. With this training, mammogram interpreters may improve their accuracy, flexibility, and automaticity in their working performance.


University of Miami
Keith Webster
“Targeting Pro-Apoptotic Bnip3”

No abstract available.

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